CUSIP No. 81724W 10 4

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SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

_____________________

SCHEDULE 13G

(Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT

TO RULES 13d-1(b),(c) AND (d) AND AMENDMENTS THERETO FILED

PURSUANT TO RULE 13d-2(b)

(Amendment No. 1)¹

SenoRx, Inc.

(Name of Issuer)

Common Stock, $.001 par value

(Title of Class of Securities)

81724W 10 4

(CUSIP Number)

December 31, 2008

Date of Event Which Requires Filing of this Statement

Check the appropriate box to designate the rule pursuant to which this Schedule is Filed:

o Rule 13d-1(b)

o Rule 13d-1(c)

x Rule 13d-1(d)

_______________________

¹The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act.

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1)	Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only)	Domain Partners IV, L.P.
2)	Check the Appropriate Box if a Member of a Group	(a) x (b) o
3)	SEC Use Only
4)	Citizenship or Place of Organization	Delaware
Number of Shares Beneficially Owned by Each Reporting Person With		5)	Sole Voting Power	1,169,067 shares of Common Stock
		6)	Shared Voting Power	-0-
		7)	Sole Dispositive Power	1,169,067 shares of Common Stock
		8)	Shared Dispositive Power	-0-
9)	Aggregate Amount Beneficially Owned by Each Reporting Person	1,169,067 shares of Common Stock
10)	Check if the Aggregate Amount in Row (9) Excludes Certain Shares
11)	Percent of Class Represented by Amount in Row (9)	6.7%
12)	Type of Reporting Person	PN

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1)	Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only)	DP IV Associates, L.P.
2)	Check the Appropriate Box if a Member of a Group	(a) x (b) o
3)	SEC Use Only
4)	Citizenship or Place of Organization	Delaware
Number of Shares Beneficially Owned by Each Reporting Person With		5)	Sole Voting Power	20,634 shares of Common Stock
		6)	Shared Voting Power	-0-
		7)	Sole Dispositive Power	20,634 shares of Common Stock
		8)	Shared Dispositive Power	-0-
9)	Aggregate Amount Beneficially Owned by Each Reporting Person	20,634 shares of Common Stock
10)	Check if the Aggregate Amount in Row (9) Excludes Certain Shares
11)	Percent of Class Represented by Amount in Row (9)	0.1%
12)	Type of Reporting Person	PN

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Amendment No. 1 to Schedule 13G

Reference is hereby made to the statement on Schedule 13G filed with the Securities and Exchange Commission on February 7, 2008 (the “Schedule 13G”). Terms defined in the Schedule 13G are used herein as so defined.

The following Items of the Schedule 13G are hereby amended and restated as follows:

Item 4

–

Ownership.

(a)

Amount Beneficially Owned:

Domain IV: 1,169,067 shares of Common Stock

DP IV A: 20,634 shares of Common Stock

(b) Percent of Class:

Domain IV: 6.7%

DP IV A: 0.1%

(c)

Number of shares as to which such person has:

(i)

sole power to vote or to direct the vote:

Domain IV: 1,169,067 shares of Common Stock

DP IV A: 20,634shares of Common Stock

(ii) shared power to vote or to direct the vote: -0-

(iii) sole power to dispose or to direct the disposition of:

Domain IV: 1,169,067 shares of Common Stock

DP IV A: 20,634shares of Common Stock

(iv) shared power to dispose or to direct the disposition of: -0-

In addition, One Palmer Square Associates IV, L.L.C., which is the sole general partner of Domain IV and DP IV A, holds 31,151 shares of Common Stock, or approximately 0.2% of the class.

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Signature:

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

	DOMAIN PARTNERS IV, L.P.
	By:	One Palmer Square Associates IV, L.L.C., General Partner
	By:	/s/ Kathleen K. Schoemaker
		Managing Member
	DP IV ASSOCIATES, L.P.
	By:	One Palmer Square Associates IV, L.L.C., General Partner
	By:	/s/ Kathleen K. Schoemaker
		Managing Member

Dated: February 3, 2009